ABSTRACT
PURPOSE: This study was conducted to investigate the relationship between atopic dermatitis and dietary fat and fatty acid (FA) intakes in 9 ~ 11 year old children. METHODS: We analyzed data from the combined 2013 ~ 2015 KNHANES (Korean National Health and Nutrition Examination Survey). Subjects were divided into two groups according to atopic dermatitis (AD); with AD and without AD. Data pertaining to macronutrients and FA intakes were obtained by a single 24-h dietary recall. Food sources were identified based on the amounts of total fat and FA consumption according to each food. The associations between each FA intake and atopic dermatitis were analyzed using simple and multiple logistic regression analyses. Age, sex, body mass index (BMI) and income levels were adjusted as covariates. RESULTS: Of the participants, 17.69% suffered from atopic dermatitis. Children with AD had significantly lower fat percentages of total energy and higher carbohydrate percentages of total energy than normal children. Percentages of energy and intakes of polyunsaturated fatty acid (PUFA), n-3 FA and n-6 FA in children with AD were significantly lower than those in normal children. In the FA, linoleic acid, γ-linoleic acid and α-linolenic acid levels of children with AD were significantly lower than those of normal children. However, the P/S ratio and n-6/n-3 ratio did not differ significantly between children with AD and normal children. Soybean oil was the main contributor to PUFA, n-3 FA and n-6 FA in both groups, while perilla seed oil and mackerel were the major food sources of n-3 FA in children with atopic dermatitis. Atopic dermatitis was significantly correlated with low-fat and high-carbohydrate diets. The adjusted odds ratios were 0.966, 0.776 and 0.963 for PUFA, n-3 FA, and n-6 FA intakes, respectively. CONCLUSION: The present study provides reliable evidence regarding the relationship between fat and FA intakes and AD in Korean children 9 ~ 11 years of age.
Subject(s)
Child , Humans , Body Mass Index , Dermatitis, Atopic , Diet , Dietary Fats , Linoleic Acid , Logistic Models , Odds Ratio , Perciformes , Perilla , Soybean OilABSTRACT
Objective: The aim of our work was to investigate the effects of n-3 polyunsaturated fatty acids on apoptosis, granzyme B and perforin expression of intestinal epithelial cells of chronic rejection after small intestinal transplantation. Methods: Small bowel transplantation was performed and rats were divided into three groups: Group 1, Lewis-to-Lewis, group 2, F344-to-Lewis, dietary corn oil, Group 3, F344-to-Lewis, dietary fish oil. All recipients were killed after 16 weeks of posttransplantation. The apoptosis rate of mucosal cells were evaluated by flow cytometry. The expressions of granzyme B and perforin were analyzed by reverse transcriptase RT-PCR. Results: A high apoptotic rate was observed when the allografts demonstrated one or more histological features of chronic rejection. N-3 polyunsaturated fatty acids decreased the rate of the apoptosis and inhibitted the expressions of granzyme B and perforin. Conclusion: N-3 polyunsaturated fatty acids can suppress the chronic rejection in small intestinal transplantation.
ABSTRACT
PURPOSE: To observe cardiovascular and metabolic changes due to canola oil diet (rich in n-3 fatty acid). METHODS: Forty five rats were followed during 15 months separated in three groups. In group aged (A), they received a regular diet. In group H, animals received a hyperlipidic diet and in group O they received a canola oil diet. The rats were fed for 15 months after weaning. At the end of the experience a blood analysis was performed and heart and aorta were analyzed. The total lipids were extracted and the LDL, VLDL and HDL were determined. RESULTS: Total cholesterol and triglyceride levels were not different among groups. Differences were found in body and cardiac weight, the thickness of the right and left ventricular wall, aorta and pulmonary diameters, HDL and LDL (p < 0.05). Smallest values of the cardiac weight and thickness of the ventricular walls were found in group O. The aorta and pulmonary internal diameters were smaller in group H. The HDL was 40greater in group O than in groups A and H while the LDL was more than 80lower in group O than in groups A and H. Differences in survival curves between groups H x A and between H x O were significant (p < 0.05) but not between groups A x O (p = 0.48). CONCLUSION: Aged rats fed with canola oil diet (rich in n-3 fatty acid) presented morphological cardiovascular and metabolic changes less important in magnitude than old animals and, mainly, the same age animals under hyperlipidic diet.